Role of Helicobacter pylori plasticity region genes in development of gastroduodenal diseases.

Plasticity region gene status in H . pylori 1 1 Role of Helicobacter pylori plasticity region genes for development of 1 gastroduodenal diseases 2 3 Short Title : Plasticity region in H

Roles of the plasticity regions of Helicobacter pylori in gastroduodenal pathogenesis.

Putative virulence genes of Helicobacter pylori are generally classified into three categories: strain-specific genes, phase-variable genes and genes with variable structures/genotypes. Among these, there has recently been considerable interest in strain-specific genes found outside of the cag pathogenicity island, especially genes in the plasticity regions. Nearly half of the strain-specific g...

Associations between the Plasticity Region Genes of Helicobacter pylori and Gastroduodenal Diseases in a High-Prevalence Area.

BACKGROUND/AIMS Genes associated with the Helicobacter pylori (H. pylori) plasticity region may play a role in the pathogenesis of H. pylori. We compared the genes jhp0940, jhp0947, and jhp0986 in H. pylori isolates from patients with different gastroduodenal diseases and in different age groups. METHODS The H. pylori hyperplasticity region genes jhp0940, jhp0947, and jhp0986 were studied by ...

Helicobacter pylori plasticity region genes are associated with the gastroduodenal diseases manifestation in India

BACKGROUND Almost all Helicobacter pylori infected person develop gastritis and severe gastritis is supposed to be the denominator of peptic ulcer diseases, which may lead to gastric cancer. However, it is still an enigma why few strains are associated with ulcer formation, while others are not related with any disease outcome. Although a number of putative virulence factors have been reported ...

Crystal Structure Confirmation of JHP933 as a Nucleotidyltransferase Superfamily Protein from Helicobacter pylori Strain J99

Helicobacter pylori is a well-known pathogen involved in the development of peptic ulcer, gastric adenocarcinoma and other forms of gastric cancer. Recently, there has been more considerable interest in strain-specific genes located in plasticity regions with great genetic variability. However, little is known about many of these genes. Studies suggested that certain genes in this region may pl...